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Endocrinology

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SPISE

Single-point estimator of insulin sensitivity.

Formula:
SPISE = 600 × HDL0.185 Triglycerides0.2 × BMI1.338
Interpretation:

SPISE estimates insulin sensitivity; the original 6.61 cutoff should be interpreted within the validated population.

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What is SPISE?

SPISE is a simple marker used to estimate insulin sensitivity from HDL cholesterol, triglycerides, and BMI.

Clinical utility

SPISE is currently best viewed as a screening and research tool, not as a diagnostic standard. It may be useful for:

  • patients with obesity;
  • cardiometabolic risk assessment;
  • identifying people with probable insulin resistance when fasting insulin is not available.
Note: MedicalC is NOT medical software and does NOT issue diagnoses or treatment recommendations. The calculators are for educational and informational purposes, use published medical formulas, and are not a substitute for medical consultation. Results should be interpreted by professionals.Read the full disclaimer.